Cathepsin K antibody (AA 163-274)

Catalog No. ABIN6939219

The Mouse Monoclonal anti-Cathepsin K antibody has been validated for IHC and StM. It is suitable to detect Cathepsin K in samples from Human.

Quick Overview for Cathepsin K antibody (AA 163-274) (ABIN6939219)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Immunohistochemistry (IHC), Staining Methods (StM)

Clone: CTSK-2791

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 163-274

Purification: Purified by Protein A/G

Immunogen: Recombinant fragment of human Cathepsin K protein (around aa 163-274) (exact sequence is proprietary)

Isotype: IgG1 kappa

Application Details

Application Notes:

Positive Control: Human liver or breast tissue (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-80 °C

Storage Comment: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Expiry Date: 24 months

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: CTSK

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Molecular Weight: 39kDa

Gene ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades