S1PR1 antibody (pThr236) (HRP)

Catalog No. ABIN6943206

Product Details anti-S1PR1 Antibody (HRP)

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Binding Specificity: pThr236

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human EDG1 around the phosphorylation site of Thr236

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Alternative Name: EDG1 (S1PR1 Products)

Background:

Synonyms: EDG1 (phospho T236), p-EDG1 (phospho T236), CD363, CHEDG 1, CHEDG1, D1S3362, ECGF 1, ECGF1, EDG 1, EDG1, endothelial differentiation G protein coupled receptor 1, Endothelial differentiation G-protein coupled receptor 1, Endothelial differentiation sphingolipid G protein coupled receptor 1, FLJ58121, G protein coupled sphingolipid receptor, g protein-coupled receptor edg-1, S1P receptor 1, S1P receptor Edg 1, S1P receptor Edg-1, S1P receptor Edg1, S1P(1) receptor, S1P1, s1pr1, S1PR1_HUMAN, sphingolipid g-protein-coupled receptor 1, Sphingosine 1 phosphate receptor Edg 1, Sphingosine 1 phosphate receptor EDG1, sphingosine 1- phosphate receptor 1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1phosphate receptor type 1 S1P1.

Background: This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene ID: 1901

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2