S1PR1 antibody (pThr236) (HRP)

Catalog No. ABIN6943206

This Rabbit Polyclonal antibody specifically detects S1PR1 in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for S1PR1 antibody (pThr236) (HRP) (ABIN6943206)

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR1 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA

Product Details anti-S1PR1 Antibody (HRP)

Binding Specificity: pThr236

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human EDG1 around the phosphorylation site of Thr236

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for S1PR1

Target: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Alternative Name: EDG1

Background:

Synonyms: EDG1 (phospho T236), p-EDG1 (phospho T236), CD363, CHEDG 1, CHEDG1, D1S3362, ECGF 1, ECGF1, EDG 1, EDG1, endothelial differentiation G protein coupled receptor 1, Endothelial differentiation G-protein coupled receptor 1, Endothelial differentiation sphingolipid G protein coupled receptor 1, FLJ58121, G protein coupled sphingolipid receptor, g protein-coupled receptor edg-1, S1P receptor 1, S1P receptor Edg 1, S1P receptor Edg-1, S1P receptor Edg1, S1P(1) receptor, S1P1, s1pr1, S1PR1_HUMAN, sphingolipid g-protein-coupled receptor 1, Sphingosine 1 phosphate receptor Edg 1, Sphingosine 1 phosphate receptor EDG1, sphingosine 1- phosphate receptor 1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1, Sphingosine 1phosphate receptor type 1 S1P1.

Background: This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene ID: 1901

UniProt: P21453

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2