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NGFR antibody

NGFR Reactivity: Human, Rat, Mouse WB, IHC (p), IF (cc), IF (p) Host: Rabbit Monoclonal 5D4 unconjugated
Catalog No. ABIN6944403
  • Target See all NGFR Antibodies
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Reactivity
    • 155
    • 64
    • 56
    • 28
    • 26
    • 26
    • 25
    • 21
    • 11
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 86
    • 76
    • 4
    • 1
    Rabbit
    Clonality
    • 93
    • 74
    Monoclonal
    Conjugate
    • 85
    • 14
    • 11
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NGFR antibody is un-conjugated
    Application
    • 91
    • 83
    • 56
    • 47
    • 41
    • 27
    • 27
    • 19
    • 16
    • 14
    • 14
    • 12
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Purification
    Purified by Protein A.
    Immunogen
    Human p75 NGF Receptor between 350 to 450 amino acids
    Clone
    5D4
    Isotype
    IgG
    Top Product
    Discover our top product NGFR Primary Antibody
  • Application Notes
    WB(1:300-1000), IHC-P(1:200-400), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
    Restrictions
    For Research Use only
  • Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Expiry Date
    12 months
  • Target
    NGFR (Nerve Growth Factor Receptor (NGFR))
    Alternative Name
    p75 NGF Receptor (NGFR Products)
    Background

    The low affinity NGFR (Nerve growth factor receptor) is a 75 kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis.


    Synonyms: Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, p75 ICD, CD_antigen: CD271, NGF receptor, NGFR
    Gene ID
    4804
    UniProt
    P08138
    Pathways
    NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding
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