PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 580-630) (HRP)

Details for Product anti-PARP1 Antibody No. ABIN6944422
Target
Binding Specificity
AA 580-630
44
34
31
15
15
13
12
12
9
9
9
9
9
9
9
9
9
9
8
8
7
7
5
5
5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse, Rat
326
92
68
32
32
16
12
11
8
8
5
5
4
3
2
1
1
1
1
1
1
1
1
Host
Rabbit
301
54
1
1
Clonality
Polyclonal
Conjugate
This PARP1 antibody is conjugated to HRP
24
17
16
16
16
14
9
8
8
8
8
8
3
3
3
3
3
Application
Western Blotting (WB)
205
164
81
50
40
30
30
30
29
24
18
6
6
3
3
2
1
1
Options
Immunogen KLH conjugated synthetic peptide derived from human PARP1
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PARP1 (PARP1 Antibody Abstract)
Background

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008].


Synonyms: ADP ribosyltransferase (NAD+, poly (ADP ribose) polymerase), ADP ribosyltransferase NAD+, ADPRT 1, ADPRT, ADPRT1, msPARP, NAD(+) ADP ribosyltransferase 1, pADPRT 1, pADPRT1, PARP 1, PARP1, PARP-1, Poly (ADP ribose) polymerase 1, poly (ADP ribose) polymerase family, member 1, Poly adenosine diphosphate ADP ribose polymerase, Poly ADP ribose polymerase 1, Poly ADP ribose polymerase family member 1, Poly ADP ribose synthetase 1, poly(ADP ribose) synthetase, poly(ADP ribosyl)transferase, Poly[ADP ribose] synthetase 1, PPOL, sPARP 1, sPARP1, PARP1_HUMAN.
Gene ID 142
UniProt P09874
Pathways Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
Application Notes WB(1:300-1000)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % Gentamicin.
Preservative Gentamicin sulfate
Precaution of Use This product contains Gentamicin sulfate: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Expiry Date 12 months