PPARGC1B antibody (Peroxisome Proliferator-Activated Receptor Gamma, Coactivator 1 beta)

Details for Product anti-PPARGC1B Antibody No. ABIN6944648
Target
Reactivity
Human, Rat
32
23
18
15
15
15
12
Host
Rabbit
28
3
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PPARGC1B antibody is un-conjugated
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
13
12
6
4
4
3
1
Options
Immunogen Recombinant protein within C-terminal human PGC1 beta
Clone 6H5
Isotype IgG
Purification Purified by Protein A.
Target
Alternative Name PPARGC1B (PPARGC1B Antibody Abstract)
Background

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Subcellular location: Nucleus


Synonyms: Peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B, PERC, PGC1, PGC1B, PPARGC1.
Gene ID 133522
UniProt Q86YN6
Pathways AMPK Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
Application Notes WB(1:500-2000), FCM(1:50-200)
Restrictions For Research Use only
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Expiry Date 12 months