TFF1 antibody

Catalog No. ABIN6945144

This Rabbit Monoclonal antibody specifically detects TFF1 in FACS, IHC (p), IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for TFF1 antibody (ABIN6945144)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: 4B1

Product Details anti-TFF1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: Synthetic peptide within human TFF1 aa 50-100

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: TFF1

Background:

Synonyms: Trefoil factor 1, Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1 A, Protein pS2, hP1 A, BCEI, PS2, TFF1, Estrogen Inducible Protein pS2.

Background: Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. TFF1 has been found to be a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. TFF1 may inhibit the growth of calcium oxalate crystals in urine.

Gene ID: 7031

UniProt: P04155

Pathways: EGFR Signaling Pathway