TIMP1 antibody (Biotin)

Catalog No. ABIN6945159

This Mouse Monoclonal antibody specifically detects TIMP1 in WB and IHC (p). It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for TIMP1 antibody (Biotin) (ABIN6945159)

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP1 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4C2

Product Details anti-TIMP1 Antibody (Biotin)

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein G.

Immunogen: Recombinant human TIMP-1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for TIMP1

Target: TIMP1 (TIMP Metallopeptidase Inhibitor 1 (TIMP1))

Alternative Name: TIMP-1

Background:

Synonyms: Clgi, Collagenase inhibitor, EPA, EPO, Erythroid Potentiating Activity, Fibroblast collagenase inhibitor, FLJ90373, HC, Human Collagenase Inhibitor, Metalloproteinase inhibitor 1, Metalloproteinase inhibitor 1 precursor, OTTHUMP00000023214, TIMP 1, TIMP, TIMP metallopeptidase inhibitor 1, TIMP1 protein, Tissue Inhibitor of Metalloproteinase 1, Tissue inhibitor of metalloproteinases, Tissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.

Background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].

Gene ID: 7076

UniProt: P01033