RUNX1T1 antibody (AA 100-390)

Catalog No. ABIN6147312

Product Details anti-RUNX1T1 Antibody

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Binding Specificity: AA 100-390

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX1T1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: GNDISPEIGE RVRTLVLGLV NSTLTIEEFH SKLQEATNFP LRPFVIPFLK ANLPLLQREL LHCARLAKQN PAQYLAQHEQ LLLDASTTSP VDSSELLLDV NENGKRRTPD RTKENGFDRE PLHSEHPSKR PCTISPGQRY SPNNGLSYQP NGLPHPTPPP PQHYRLDDMA IAHHYRDSYR HPSHRDLRDR NRPMGLHGTR QEEMIDHRLT DREWAEEWKH LDHLLNCIMD MVEKTRRSLT VLRRCQEADR EELNYWIRRY SDAEDLKKGG GSSSSHSRQQ SPVNPDPVAL D

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 100-390 of human RUNX1T1 (NP_783554.1).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RUNX1T1

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Alternative Name: RUNX1T1 (RUNX1T1 Products)

Synonyms: MTG8 antibody, si:ch211-232j17.1 antibody, wu:fi14b07 antibody, zgc:154044 antibody, AML1T1 antibody, CBFA2T1 antibody, CDR antibody, ETO antibody, ZMYND2 antibody, Cbfa2t1h antibody, Cbfa2t1 antibody, runt-related transcription factor 1; translocated to, 1 (cyclin D-related) antibody, RUNX1 translocation partner 1 L homeolog antibody, RUNX1 translocation partner 1 antibody, runx1t1 antibody, runx1t1.L antibody, RUNX1T1 antibody, Runx1t1 antibody

Background: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.,RUNX1T1,AML1-MTG8,AML1T1,CBFA2T1,CDR,ETO,MTG8,ZMYND2,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Tumor suppressors,RUNX1T1

Molecular Weight: 44 kDa/48 kDa/63 kDa/64 kDa/67 kDa/68 kDa

Gene ID: 862

UniProt: Q06455