LXR-alpha (N-Term) antibody

Catalog No. ABIN6972296

This Rabbit Polyclonal antibody specifically detects in ChIP-seq, ChIP and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for LXR-alpha (N-Term) antibody (ABIN6972296)

Target: LXR-alpha

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Application: ChIP DNA-Sequencing (ChIP-seq), Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)

Product Details

Binding Specificity: N-Term

Characteristics: LXR-a (Liver X receptor alpha, NR1H3) is an orphan nuclear receptor and a member of the NR1 receptor family. The LXR receptors (including LXR-a and LXR-b) bind oxysterols and play key roles in maintaining cholesterol homeostasis in macrophages, primarily by regulating multiple components of the reverse cholesterol transport. They also are potent inhibitors of inflammation and are capable of repressing cytokine and chemokine production by Toll-like receptor (TLR)-activated macrophages. LXR-a is expressed mainly in liver and adipose tissue and interacts with RXR, shifting RXR to an active ligand-binding subunit mediating responses to retinoids. LXR-alpha antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.

Purification: Affinity Purified

Immunogen: This LXR-α antibody was raised against a peptide in the N-terminal region of human LXR-α.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Purified rabbit IgG in 70 mM Tris, 105 mM EDTA, 31 mM glycine, 30 % glycerol and 0.035 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Target Details

Target: LXR-alpha

Alternative Name: LXR-α

Molecular Weight: 52 kDa

NCBI Accession: NP_005684