GPC1 antibody (AA 251-350) (AbBy Fluor® 555)

Catalog No. ABIN6978749

The Rabbit Polyclonal anti-GPC1 antibody has been validated for IF (cc), IF (p). It is suitable to detect GPC1 in samples from Rat.

Quick Overview for GPC1 antibody (AA 251-350) (AbBy Fluor® 555) (ABIN6978749)

Target: GPC1 (Glypican 1 (GPC1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPC1 antibody is conjugated to AbBy Fluor® 555

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-GPC1 Antibody (AbBy Fluor® 555)

Binding Specificity: AA 251-350

Cross-Reactivity: Rat

Predicted Reactivity: Mouse,Dog,Cow,Sheep,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse Glypican 1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GPC1

Target: GPC1 (Glypican 1 (GPC1))

Alternative Name: Glypican 1

Background:

Synonyms: FLJ38078, glypican, glypican1, GPC 1, Glypican-1, GPC1, Glypican proteoglycan 1, Gpc1, GPC1_HUMAN, Secreted glypican-1.

Background: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparin sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling.

Gene ID: 14733

UniProt: Q9QZF2

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation