Latrophilin 1 antibody (AA 201-300) (Cy7)

Catalog No. ABIN6986123

The Rabbit Polyclonal anti-Latrophilin 1 antibody has been validated for IF (cc) and IF (p). It is suitable to detect Latrophilin 1 in samples from Rat.

Quick Overview for Latrophilin 1 antibody (AA 201-300) (Cy7) (ABIN6986123)

Target: Latrophilin 1 (LPHN1)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Latrophilin 1 antibody is conjugated to Cy7

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Latrophilin 1 Antibody (Cy7)

Binding Specificity: AA 201-300

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LPHN1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Latrophilin 1

Target: Latrophilin 1 (LPHN1)

Alternative Name: LPHN1

Background:

Synonyms: Calcium independent alpha latrotoxin receptor 1, Calcium-independent alpha-latrotoxin receptor 1, CIRL-1, CIRL1, CL1, CLIBA, G protein-coupled receptor for alpha-Latrotoxin, KIAA0821, Latrophilin 1, Latrophilin-1, Latrophilin1, LEC2, Lectomedin 2, Lectomedin-2, LPHN 1, LPHN1, LPHN1_HUMAN.

Background: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

Gene ID: 22859

UniProt: O94910

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis