P4HB antibody

Catalog No. ABIN6989857

Product Details anti-P4HB Antibody

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P4HB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunofluorescence (Cultured Cells) (IF (cc))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 329-508 of human P4HB (NP_000909.2).

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IF(ICC) 1:50-200
IP(1-2 μg)
IHC()
IF()

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for P4HB

Target: P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

Alternative Name: P4HB (P4HB Products)

Synonyms: DSI antibody, ERBA2L antibody, GIT antibody, P4Hbeta antibody, PDI antibody, PDIA1 antibody, PHDB antibody, PO4DB antibody, PO4HB antibody, PROHB antibody, PDA2 antibody, PDIP antibody, PDIR antibody, ERp59 antibody, Pdia1 antibody, Thbp antibody, p55 antibody, XPDIp antibody, pdi antibody, 1810041F13Rik antibody, AI661267 antibody, Pdip antibody, Pdipl antibody, p58 antibody, prolyl 4-hydroxylase subunit beta antibody, protein disulfide isomerase family A member 2 antibody, prolyl 4-hydroxylase, beta polypeptide antibody, protein disulfide isomerase family A member 2 L homeolog antibody, protein disulfide isomerase associated 2 antibody, prolyl 4-hydroxylase subunit beta L homeolog antibody, protein disulfide-isomerase antibody, P4HB antibody, PDIA2 antibody, P4hb antibody, pdia2.L antibody, Pdia2 antibody, p4hb.L antibody, LOC8281065 antibody

Background:

Synonyms: P4HB,CLCRP1,DSI,ERBA2L,GIT,P4Hbeta,PDI,PDIA1,PHDB,PO4DB,PO4HB,PROHB

Background: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.

Gene ID: 5034

UniProt: P07237

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism