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SARS-CoV-2 Spike S2 antibody (AA 900-950)

The Rabbit Polyclonal anti-SARS-CoV-2 Spike S2 antibody has been validated for ELISA and WB. It is suitable to detect SARS-CoV-2 Spike S2 in samples from SARS Coronavirus-2 (SARS-CoV-2).
Catalog No. ABIN6990131

Quick Overview for SARS-CoV-2 Spike S2 antibody (AA 900-950) (ABIN6990131)

Target

See all SARS-CoV-2 Spike S2 Antibodies
SARS-CoV-2 Spike S2

Reactivity

SARS Coronavirus-2 (SARS-CoV-2)

Host

  • 11
  • 6
  • 6
  • 1
Rabbit

Clonality

  • 18
  • 5
Polyclonal

Conjugate

  • 21
  • 2
This SARS-CoV-2 Spike S2 antibody is un-conjugated

Application

  • 21
  • 13
  • 4
  • 3
  • 1
ELISA, Western Blotting (WB)
  • Binding Specificity

    • 2
    • 2
    • 2
    • 1
    • 1
    AA 900-950

    Purification

    SARS-CoV-2 (COVID-19) Spike Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Anti-SARS-CoV-2 (COVID-19) Spike antibody was raised against a peptide corresponding to 16 amino acids near the center terminus of SARS-CoV-2 (COVID-19) Spike glycoprotein. The immunogen is located within 900-950 amino acids of SARS-CoV-2 (COVID-19) Spike protein.

    Isotype

    IgG
  • Application Notes

    WB: 1 μ,g/mL.

    Antibody validated: SARS-CoV-2 (COVID-19) Spike antibody can be used for the detection of SARS-CoV-2 (COVID-19) Spike protein in WB. It will detect 2 ng of free peptide at 1 μ,g/mL. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    SARS-CoV-2 (COVID-19) Spike Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    SARS-CoV-2 (COVID-19) Spike antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    SARS-CoV-2 Spike S2

    Target Type

    Viral Protein

    Background

    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection (3). The spike protein is the major target for neutralizing antibodies and vaccine development (4). The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (5). The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (6).

    Gene ID

    43740568
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