Neurturin antibody (C-Term)

Catalog No. ABIN6990244

This Rabbit Polyclonal antibody specifically detects Neurturin in WB, ELISA, IHC (p) and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for Neurturin antibody (C-Term) (ABIN6990244)

Target: Neurturin (NRTN)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neurturin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Neurturin Antibody

Binding Specificity: C-Term

Purification: Neurturin Antibody is affinity chromatography purified via peptide column.

Immunogen: Neurturin antibody was raised against a 16 amino acid peptide near the carboxy terminus of human Neurturin. The immunogen is located within the last 50 amino acids of Neurturin.

Isotype: IgG

Application Details

Application Notes: Neurturin antibody can be used for detection of neurturin by Western blot. An approximate 14 kDa band of the full length recombinant NTN was detected. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Neurturin Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: Neurturin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Neurturin

Target: Neurturin (NRTN)

Alternative Name: Neurturin

Background: Neurturin Antibody: Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRalpha. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently and termed GDNFRβ, Ret ligand 2 (RETL2) or TGF-beta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα,-2 recently. NTN binds to and forms a complex with GFRα,-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.

Molecular Weight: 14 kDa

Gene ID: 4902

NCBI Accession: NP_004549

UniProt: Q99748