Claudin 4 antibody (C-Term)

Catalog No. ABIN6990468

Product Details anti-Claudin 4 Antibody

Target: Claudin 4 (CLDN4)

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least four isoforms of CLAUDIN4 are known to exist, CLAUDIN4 antibody will detect all four isoforms

Purification: CLAUDIN4 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-CLAUDIN4 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human CLAUDIN4. The immunogen is located within the last 50 amino acids of CLAUDIN4.

Isotype: IgG

Application Details

Application Notes: WB: 0.5-2 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CLAUDIN4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CLAUDIN4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Claudin 4

Target: Claudin 4 (CLDN4)

Alternative Name: CLAUDIN4 (CLDN4 Products)

Background: CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.

Molecular Weight: Predicted: 22kD

Observed: 22 kD kDa

Gene ID: 1364

NCBI Accession: NP_001296

UniProt: O14493

Pathways: Hepatitis C