Thymic Stromal Lymphopoietin antibody (AA 70-120)

Catalog No. ABIN6990708

This anti-Thymic Stromal Lymphopoietin antibody is a Rabbit Polyclonal antibody detecting Thymic Stromal Lymphopoietin in WB, ELISA, IHC (p) and IF. Suitable for Mouse and Rat.

Quick Overview for Thymic Stromal Lymphopoietin antibody (AA 70-120) (ABIN6990708)

Target: Thymic Stromal Lymphopoietin (TSLP)

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thymic Stromal Lymphopoietin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Thymic Stromal Lymphopoietin Antibody

Binding Specificity: AA 70-120

Purification: TSLP Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-TSLP antibody was raised against a peptide corresponding to 20 amino acids near the center of mouse TSLP. The immunogen is located within the amino acids 70-120 of TSLP.

Isotype: IgG

Application Details

Application Notes: WB: 0.5 - 2 μ,g/mL, IHC-P: 2.5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse and rat samples, Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TSLP Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TSLP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for Thymic Stromal Lymphopoietin

Target: Thymic Stromal Lymphopoietin (TSLP)

Alternative Name: TSLP

Background: TSLP Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. TSLP is a four-helix-bundle cytokine that is expressed mainly by barrier epithelial cells and is a potent activator of several cell types such as myeloid dendritic cells. TSLP is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Amino acid sequence analysis has shown poor homology between human and mouse TSLP although they exhibit similar biological functions and are expressed in similar tissues. At least two differentially spliced isoforms of TSLP are known to exist.

Molecular Weight: Predicted: 16 kD

Observed: 24 kD (Post-modifications: 3 N-linked glycosylations) kDa

Gene ID: 85480

NCBI Accession: NP_067342

UniProt: Q969D9