CADPS antibody (N-Term)

Catalog No. ABIN6990891

Product Details anti-CADPS Antibody

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Binding Specificity: AA 90-140, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CADPS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Numerous isoforms of CAPS1 are known to exist. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.

Purification: CAPS1 Antibody is affinity chromatography purified via peptide column.

Immunogen: CAPS1 antibody was raised against a 21 amino acid synthetic peptide near the amino terminus of the human CAPS1. The immunogen is located within amino acids 90 - 140 of CAPS1.

Isotype: IgG

Application Details

Application Notes: CAPS1 antibody can be used for detection of CAPS1 by Western blot at 0.25 - 0.5 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CAPS1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CAPS1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CADPS

Target: CADPS (Ca++-Dependent Secretion Activator (CADPS))

Alternative Name: CAPS1 (CADPS Products)

Background: CAPS1 Antibody: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles, CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

Gene ID: 8618

NCBI Accession: NP_899631

UniProt: Q9ULU8

Pathways: Synaptic Vesicle Exocytosis