CERS6 antibody (C-Term)

Catalog No. ABIN6991026

This anti-CERS6 antibody is a Rabbit Polyclonal antibody detecting CERS6 in ELISA, WB, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for CERS6 antibody (C-Term) (ABIN6991026)

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CERS6 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-CERS6 Antibody

Binding Specificity: C-Term

Specificity: At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.

Purification: LASS6 Antibody is affinity chromatography purified via peptide column.

Immunogen: LASS6 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human LASS6. The immunogen is located within the last 50 amino acids of LASS6.

Isotype: IgG

Application Details

Application Notes: LASS6 antibody can be used for detection of LASS6 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: LASS6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: LASS6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CERS6

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Alternative Name: LASS6

Background: LASS6 Antibody: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development.

Gene ID: 253782

UniProt: Q6ZMG9