CRMP1 antibody (N-Term)

Catalog No. ABIN6991044

This anti-CRMP1 antibody is a Rabbit Polyclonal antibody detecting CRMP1 in WB, ELISA, IHC (p) and IF. Suitable for Human, Mouse and Rat.

Quick Overview for CRMP1 antibody (N-Term) (ABIN6991044)

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRMP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-CRMP1 Antibody

Binding Specificity: AA 90-140, N-Term

Specificity: This antibody is expected to recognize only the longest isoform of CRMP-1.

Purification: CRMP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: CRMP1 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human CRMP1. The immunogen is located within amino acids 90 - 140 of CRMP1.

Isotype: IgG

Application Details

Application Notes: CRMP1 antibody can be used for the detection of CRMP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CRMP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CRMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CRMP1

Target: CRMP1 (Collapsin Response Mediator Protein 1 (CRMP1))

Alternative Name: CRMP1

Background: CRMP1 Antibody: Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain, later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.

Gene ID: 1400

NCBI Accession: NP_001014809

UniProt: Q14194