PDCD5 antibody (C-Term)

Catalog No. ABIN6991058

The Rabbit Polyclonal anti-PDCD5 antibody has been validated for WB, ELISA, IF and ICC. It is suitable to detect PDCD5 in samples from Human, Mouse and Rat.

Quick Overview for PDCD5 antibody (C-Term) (ABIN6991058)

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDCD5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-PDCD5 Antibody

Binding Specificity: C-Term

Purification: PDCD5 Antibody is affinity chromatography purified via peptide column.

Immunogen: PDCD5 antibody was raised against a 21 amino acid synthetic peptide from near the carboxy terminus of human PDCD5. The immunogen is located within the last 50 amino acids of PDCD5.

Isotype: IgG

Application Details

Application Notes: PDCD5 antibody can be used for detection of PDCD5 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PDCD5 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PDCD5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PDCD5

Target: PDCD5 (Programmed Cell Death 5 (PDCD5))

Alternative Name: PDCD5

Background: PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Gene ID: 9141

UniProt: O14737