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ZFYVE26 antibody (C-Term)

The Rabbit Polyclonal anti-ZFYVE26 antibody has been validated for ELISA, WB and IF. It is suitable to detect ZFYVE26 in samples from Human, Mouse and Rat.
Catalog No. ABIN6991064

Quick Overview for ZFYVE26 antibody (C-Term) (ABIN6991064)

Target

See all ZFYVE26 Antibodies
ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

Reactivity

  • 10
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Mouse, Rat

Host

  • 10
Rabbit

Clonality

  • 10
Polyclonal

Conjugate

  • 6
  • 2
  • 1
  • 1
This ZFYVE26 antibody is un-conjugated

Application

  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
ELISA, Western Blotting (WB), Immunofluorescence (IF)
  • Binding Specificity

    • 5
    • 2
    • 1
    • 1
    • 1
    AA 1710-1760, C-Term

    Specificity

    Multiple isoforms of SPG15 are known to exist.

    Purification

    SPG15 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    SPG15 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SPG15. The immunogen is located within amino acids 1710 - 1760 of SPG15.

    Isotype

    IgG
  • Application Notes

    SPG15 antibody can be used for detection of SPG15 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    SPG15 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    SPG15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    ZFYVE26 (Zinc Finger, FYVE Domain Containing 26 (ZFYVE26))

    Alternative Name

    SPG15

    Background

    SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking.

    Molecular Weight

    Predicted: 280 kDa

    Observed: 260 kDa

    Gene ID

    23503

    UniProt

    Q68DK2
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