CCDC134 antibody (N-Term)

Catalog No. ABIN6991156

This Rabbit Polyclonal antibody specifically detects CCDC134 in ELISA, WB, IHC (p) and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CCDC134 antibody (N-Term) (ABIN6991156)

Target: CCDC134 (Coiled-Coil Domain Containing 134 (CCDC134))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCDC134 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-CCDC134 Antibody

Binding Specificity: N-Term

Purification: CCDC134 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCDC134 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CCDC134. The immunogen is located within the first 50 amino acids of CCDC134.

Isotype: IgG

Application Details

Application Notes: CCDC134 antibody can be used for detection of CCDC134 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CCDC134 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CCDC134 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for CCDC134

Target: CCDC134 (Coiled-Coil Domain Containing 134 (CCDC134))

Alternative Name: CCDC134

Background: CCDC134 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.

Gene ID: 79879

NCBI Accession: NP_079097

UniProt: Q9H6E4