RUSC1 antibody (C-Term)

Catalog No. ABIN6991195

This Rabbit Polyclonal antibody specifically detects RUSC1 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RUSC1 antibody (C-Term) (ABIN6991195)

Target: RUSC1 (RUN and SH3 Domain Containing 1 (RUSC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUSC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-RUSC1 Antibody

Binding Specificity: AA 780-830, C-Term

Purification: RUSC1 Antibody is affinity chromatography purified via peptide column.

Immunogen: RUSC1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RUSC1. The immunogen is located within amino acids 780 - 830 of RUSC1.

Isotype: IgG

Application Details

Application Notes: RUSC1 antibody can be used for detection of RUSC1 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: RUSC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: RUSC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for RUSC1

Target: RUSC1 (RUN and SH3 Domain Containing 1 (RUSC1))

Alternative Name: RUSC1

Background: RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30 % amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Iκ,B kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κ,B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κ,B activation pathway.

Gene ID: 23623

NCBI Accession: NP_001098673

UniProt: Q9BVN2