PLEKHO1 antibody (C-Term)

Catalog No. ABIN6991202

The Rabbit Polyclonal anti-PLEKHO1 antibody has been validated for ELISA and WB. It is suitable to detect PLEKHO1 in samples from Human, Mouse and Rat.

Quick Overview for PLEKHO1 antibody (C-Term) (ABIN6991202)

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLEKHO1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-PLEKHO1 Antibody

Binding Specificity: C-Term

Purification: CKIP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: CKIP1 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human CKIP1. The immunogen is located within the last 50 amino acids of CKIP1.

Isotype: IgG

Application Details

Application Notes: CKIP1 antibody can be used for detection of CKIP1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: CKIP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: CKIP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PLEKHO1

Target: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Alternative Name: CKIP1

Background: CKIP1 Antibody: CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.

Gene ID: 51177

NCBI Accession: NP_057358

UniProt: Q53GL0