PLAC1 antibody (C-Term)

Catalog No. ABIN6991427

The Rabbit Polyclonal anti-PLAC1 antibody has been validated for ELISA, WB, IF and ICC. It is suitable to detect PLAC1 in samples from Human.

Quick Overview for PLAC1 antibody (C-Term) (ABIN6991427)

Target: PLAC1 (Placenta-Specific 1 (PLAC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLAC1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-PLAC1 Antibody

Binding Specificity: AA 130-180, C-Term

Purification: PLAC1 Antibody is affinity chromatography purified via peptide column.

Immunogen: PLAC1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human PLAC1. The immunogen is located within amino acids 130 - 180 of PLAC1.

Isotype: IgG

Application Details

Application Notes: PLAC1 antibody can be used for detection of PLAC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PLAC1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: PLAC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for PLAC1

Target: PLAC1 (Placenta-Specific 1 (PLAC1))

Alternative Name: PLAC1

Background: PLAC1 Antibody: PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.

Gene ID: 10761

NCBI Accession: NP_068568

UniProt: Q9HBJ0