AXIN2 antibody (C-Term)

Catalog No. ABIN6991479

This anti-AXIN2 antibody is a Rabbit Polyclonal antibody detecting AXIN2 in WB, ELISA, IF and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for AXIN2 antibody (C-Term) (ABIN6991479)

Target: AXIN2 (Axin 2 (AXIN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AXIN2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AXIN2 Antibody

Binding Specificity: AA 780-830, C-Term

Specificity: AXIN2 antibody is predicted to not cross-react with AXIN1. At least four isoforms of AXIN2 are known to exist, this antibody will recognize all four.

Purification: AXIN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: AXIN2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human AXIN2. The immunogen is located within amino acids 780 - 830 of AXIN2.

Isotype: IgG

Application Details

Application Notes: AXIN2 antibody can be used for detection of AXIN2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: AXIN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: AXIN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for AXIN2

Target: AXIN2 (Axin 2 (AXIN2))

Alternative Name: AXIN2

Background: AXIN2 Antibody: Like the related protein AXIN1, AXIN2 is thought to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway. In mouse, AXIN2 organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and AXIN2, which leads to the degradation of beta-catenin, which is thought to be an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.

Molecular Weight: 85, 93 kDa

Gene ID: 8313

UniProt: Q9Y2T1

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling