2B4 antibody (C-Term)

Catalog No. ABIN6991513

This Rabbit Polyclonal antibody specifically detects 2B4 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for 2B4 antibody (C-Term) (ABIN6991513)

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 2B4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-2B4 Antibody

Binding Specificity: C-Term

Specificity: At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.

Purification: SLAMF4 Antibody is affinity chromatography purified via peptide column.

Immunogen: SLAMF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SLAMF4. The immunogen is located within the last 50 amino acids of SLAMF4.

Isotype: IgG

Application Details

Application Notes: SLAMF4 antibody can be used for detection of SLAMF4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SLAMF4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SLAMF4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for 2B4

Target: 2B4 (CD244) (Natural Killer Cell Receptor 2B4 (CD244))

Alternative Name: SLAMF4

Background: SLAMF4 Antibody: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.

Gene ID: 51744

NCBI Accession: NP_1160135

UniProt: Q9BZW8