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DIS3 antibody (N-Term)

DIS3 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991861
  • Target See all DIS3 Antibodies
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Binding Specificity
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 90-140, N-Term
    Reactivity
    • 44
    • 15
    • 7
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 39
    • 5
    Rabbit
    Clonality
    • 42
    • 2
    Polyclonal
    Conjugate
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DIS3 antibody is un-conjugated
    Application
    • 33
    • 21
    • 15
    • 6
    • 5
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificity
    Multiple isoforms of DIS3 are known to exist.
    Purification
    DIS3 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.
    Isotype
    IgG
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    Discover our top product DIS3 Primary Antibody
  • Application Notes
    DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DIS3 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))
    Alternative Name
    DIS3 (DIS3 Products)
    Synonyms
    EXOSC11 antibody, KIAA1008 antibody, RP11-342J4.3 antibody, RRP44 antibody, bA555G22.1 antibody, dis3p antibody, DIS3 antibody, 2810028N01Rik antibody, RGD1304646 antibody, wu:fb08g12 antibody, dis3 antibody, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 exosome endoribonuclease and 3'-5' exoribonuclease antibody, DIS3 antibody, Dis3 antibody, dis3 antibody, dis3.L antibody
    Background
    DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.
    Molecular Weight
    Predicted: 105 kDa

    Observed: 103 kDa
    Gene ID
    22894
    NCBI Accession
    NP_055768
    UniProt
    Q9Y2L1
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