IL-22 antibody (AA 90-140)

Catalog No. ABIN6991937

The Rabbit Polyclonal anti-IL-22 antibody has been validated for WB, ELISA, ICC and IF. It is suitable to detect IL-22 in samples from Human, Mouse and Rat.

Quick Overview for IL-22 antibody (AA 90-140) (ABIN6991937)

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-22 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-IL-22 Antibody

Binding Specificity: AA 90-140

Specificity: IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.

Purification: IL-22 antibody is affinity chromatography purified via peptide column.

Immunogen: IL-22 antibody was raised against a 17 amino acid peptide near the center of human IL-22 . The immunogen is located within amino acids 90 - 140 of IL-22.

Isotype: IgG

Application Details

Application Notes: IL-22 antibody can be used for detection of IL-22 by Western blot at 0.5 μ,g/mL. Antibody can also be used for Immunocytochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IL-22 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IL-22 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IL-22

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Alternative Name: IL-22

Background: Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).

Molecular Weight: Predicted: 20 kDa

Observed: 17 kDa

Gene ID: 50616

NCBI Accession: NP_065386

UniProt: Q9GZX6