IFIT3 antibody (C-Term)

Catalog No. ABIN6991994

The Rabbit Polyclonal anti-IFIT3 antibody has been validated for WB, ELISA and IHC (p). It is suitable to detect IFIT3 in samples from Human.

Quick Overview for IFIT3 antibody (C-Term) (ABIN6991994)

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IFIT3 Antibody

Binding Specificity: AA 380-430, C-Term

Specificity: IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.

Purification: IFIT3 antibody is affinity chromatography purified via peptide column.

Immunogen: IFIT3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human IFIT3. The immunogen is located within amino acids 380 - 430 of IFIT3 .

Isotype: IgG

Application Details

Application Notes: IFIT3 antibody can be used for detection of IFIT3 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: IFIT3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: IFIT3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for IFIT3

Target: IFIT3 (Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3))

Alternative Name: IFIT3

Background: The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2). These proteins have been suggested to induce anti-viral cellular activities in response to infection (2). IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3).

Molecular Weight: Predicted: 54 kDa

Observed: 50 kDa

Gene ID: 3437

NCBI Accession: NP_001026853

UniProt: O14879