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TIM3 antibody (Extracellular Domain)

This Mouse Monoclonal antibody specifically detects TIM3 in FACS, ELISA, ICC, IF and IHC (p). It exhibits reactivity toward Human.
Catalog No. ABIN6992278

Quick Overview for TIM3 antibody (Extracellular Domain) (ABIN6992278)

Target

See all TIM3 (TIM 3) Antibodies
TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

Reactivity

  • 112
  • 38
  • 4
  • 3
  • 2
  • 1
  • 1
Human

Host

  • 59
  • 53
  • 28
  • 2
  • 2
  • 2
  • 1
Mouse

Clonality

  • 95
  • 50
  • 2
Monoclonal

Conjugate

  • 85
  • 12
  • 9
  • 9
  • 8
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TIM3 antibody is un-conjugated

Application

  • 60
  • 58
  • 53
  • 39
  • 20
  • 18
  • 17
  • 12
  • 6
  • 5
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone

1C6
  • Binding Specificity

    • 52
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain

    Purification

    TIM-3 Antibody is supplied as protein A purified IgG2b.

    Immunogen

    TIM-3 antibody was raised against the extracellular domain of human TIM-3

    Isotype

    IgG2b kappa
  • Application Notes

    TIM-3 antibody can be used for ELISA starting at 0.1 μ,g/mL. For Immunocytochemistry start at 1 μ,g/mL. For Immunofluorescence start at 10 μ,g/mL. For Immunohistochemistry start at 5 μ,g/mL. For Flow Cytometry start at 0.1 μ,g/mL.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    TIM-3 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    -20 °C,4 °C

    Storage Comment

    TIM-3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))

    Alternative Name

    TIM3

    Target Type

    Virus

    Background

    The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-? producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice, blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

    Gene ID

    84868

    NCBI Accession

    NP_116171

    UniProt

    Q8TDQ0

    Pathways

    Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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