HORMAD2 antibody

Catalog No. ABIN7247717

This Rabbit Polyclonal antibody specifically detects HORMAD2 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for HORMAD2 antibody (ABIN7247717)

Target: HORMAD2 (HORMA Domain Containing 2 (HORMAD2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HORMAD2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-HORMAD2 Antibody

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human HORMAD2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.32 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HORMAD2

Target: HORMAD2 (HORMA Domain Containing 2 (HORMAD2))

Alternative Name: HORMAD2

Background: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).

UniProt: Q8N7B1