PGC antibody

Catalog No. ABIN7260655

This anti-PGC antibody is a Rabbit Polyclonal antibody detecting PGC in WB. Suitable for Human, Rat and Mouse.

Quick Overview for PGC antibody (ABIN7260655)

Target: PGC (Pepsinogen C (PGC))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PGC antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PGC Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human Pepsinogen II (NP_001159896.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PGC

Target: PGC (Pepsinogen C (PGC))

Alternative Name: Pepsinogen II

Background: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.

Molecular Weight:

Observed_MW: 45-50 kDa

Calculated_MW: 34 kDa/42 kDa

Gene ID: 5225

UniProt: P20142