ITGA5 antibody

Catalog No. ABIN7013949

This Rat Monoclonal antibody specifically detects ITGA5 in FACS, IHC (fro), ICC and Func. It exhibits reactivity toward Mouse.

Quick Overview for ITGA5 antibody (ABIN7013949)

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This ITGA5 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Functional Studies (Func)

Clone: 5H10-27 (MFR5)

Product Details anti-ITGA5 Antibody

Purpose: Anti-Ms CD49e Purified Azide Free

Specificity: The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.

Purification: Purified by protein-G affinity chromatography.

Immunogen: C57BL/6 x A/J)F1 murine mast cell line

Isotype: IgG2a kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.
Functional application: Blocking

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for ITGA5

Target: ITGA5 (Integrin, alpha 5 (ITGA5))

Alternative Name: CD49e

Background: Integrin alpha 5,CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. VLA-5 binds to RGD sequence of fibronectin, and to neural adhesion molecule L1. It is important in maintaining the integrity of endothelial monolayers, in monocyte migration into the extracellular tissues, and it also provides a co-stimulatory signal to T cells and enhances receptor and complement receptor-mediated phagocytosis.,ITGA5, VLA-5 alpha, FNRA

Gene ID: 16402

UniProt: P11688

Pathways: Integrin Complex