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Neuropilin 1 antibody (Extracellular) (FITC)

NRP1 Reactivity: Human FACS Host: Rabbit Polyclonal FITC
Catalog No. ABIN7043379
  • Target See all Neuropilin 1 (NRP1) Antibodies
    Neuropilin 1 (NRP1)
    Binding Specificity
    • 15
    • 8
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 502-514, Extracellular
    Reactivity
    • 97
    • 55
    • 47
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 94
    • 24
    • 4
    • 3
    Rabbit
    Clonality
    • 90
    • 35
    Polyclonal
    Conjugate
    • 55
    • 18
    • 13
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Neuropilin 1 antibody is conjugated to FITC
    Application
    • 89
    • 35
    • 32
    • 23
    • 15
    • 14
    • 13
    • 11
    • 6
    • 6
    • 4
    • 4
    • 1
    • 1
    Flow Cytometry (FACS)
    Purpose
    A Rabbit Polyclonal Antibody to Neuropilin-1 (NRP1) (extracellular) conjugated to the fluorescent dye FITC.
    Specificity
    Extracellular, N-terminus
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Rat,mouse - identical
    Characteristics
    Anti-Neuropilin-1 (NRP1) (extracellular) Antibody (ABIN7043378, ABIN7044702 and ABIN7044703) is a highly specific antibody directed against an extracellular epitope of the human protein. The antibody can be used in western blot, immunocytochemistry, and live cell flow cytometry applications. It has been designed to recognize NRP1 from human, mouse, and rat samples. \nAnti-Neuropilin-1 (NRP1)-FITC Antibody (ABIN7043378, ABIN7044702 and ABIN7044703)-F) is directly conjugated to fluorescein isothiocyanate (FITC) fluorophore. This conjugated antibody has been developed to be used in immunofluorescent applications such as direct flow cytometry and live cell imaging.
    Purification
    Affinity purified on immobilized antigen.
    Immunogen

    Immunogen: Synthetic peptide

    Immunogen Sequence: (C)GGKHRENKVFMRK, corresponding to amino acid residues 502-514 of human neuropilin-1

    Isotype
    IgG
    Top Product
    Discover our top product NRP1 Primary Antibody
  • Application Notes

    Antigen preadsorption control: 1 μg peptide per 1 μg antibody

    Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

    Application Dilutions Western blot wb: N/A

    Comment

    Negative Control: (ABIN7582044)

    Blocking Peptide: (ABIN7236114)

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Recosntitute with double distilled water (DDW) to a concentration of 1.0 mg/mL.
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment

    Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

    Storage after reconstitution: The reconstituted solution can be stored at 4°C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

  • Target
    Neuropilin 1 (NRP1)
    Alternative Name
    NRP1 (NRP1 Products)
    Background
    Vascular endothelial cell growth factor 165 receptor, VEGF165R, CD304,Neuropilins (NRPs) are co-receptors for class 3 semaphorins, polypeptides with key roles in axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines.Neuropilin 1 (NRP1) is a transmembrane glycoprotein and comprises a large extracellular region containing multiple domains, a single transmembrane domain and a small cytoplasmic domain, also with a number of protein interacting domains.Class 3 semaphorins bind NRP1 (and NRP2) with different, and partially overlapping, specificities and affinities. Plexin A1 and Plexin A2 are the major signaling receptors for class 3 semaphorins, and complex with NRPs and semaphorins to form a holoreceptor essential for mediating effects of semaphorins on growth-cone collapse and axonal guidance in neurogenesis. The major VEGF-A signaling receptor, VEGF receptor 2, forms complexes with NRP1 and is important for optimal VEGFR2 signaling and function in endothelial cells.Targeted disruption of the NRP1 gene has demonstrated an essential dual role of these molecules in neurogenesis and cardiovascular development. NRP1-null mice die with a spectrum of cardiovascular and neuronal defects1.

    Alternative names: Vascular endothelial cell growth factor 165 receptor, VEGF165R, CD304
    Gene ID
    8829
    NCBI Accession
    NM_001024628
    UniProt
    O14786
    Pathways
    Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals
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