UTS2R antibody (AA 154-167)

Catalog No. ABIN7043874

This anti-UTS2R antibody is a Rabbit Polyclonal antibody detecting UTS2R in WB and IHC. Suitable for Rat.

Quick Overview for UTS2R antibody (AA 154-167) (ABIN7043874)

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UTS2R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-UTS2R Antibody

Binding Specificity: AA 154-167

Purpose: A Rabbit Ployclonal Antibody to Urotensin II Receptor

Specificity: 2nd intracellular loop

Predicted Reactivity: Bovine - identical, human,canine - 13,14 amino acid residues identical

Characteristics: Anti-Urotensin II Receptor Antibody is directed against the 2nd cytoplasmic loop of the rat UTS2R. Anti-Urontenisn II Receptor Antibody (ABIN7043874 and ABIN7044242) can be used in western blot and immunohistochemical applications, and recognizes UTS2R in rat samples.

Purification: Affinity purified on immobilized antigen.

Immunogen:

Immunogen: Synthetic peptide

Immunogen Sequence: (C)RPLDTVQRSKGYRK, corresponding to amino acid residues 154-167 of rat URIIR

Isotype: IgG

Application Details

Application Notes:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: N/A

Application Dilutions Western blot wb: 1:200

Comment:

Cited Application: IHC

Negative Control: (ABIN7237551)

Blocking Peptide: (ABIN7237551)

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Storage: 4 °C,-20 °C

Storage Comment:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Details for UTS2R

Target: UTS2R (Urotensin 2 Receptor (UTS2R))

Alternative Name: UTS2R

Background: Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14,Urotensin II is a powerful vasoconstrictive substance. The human urotensin II receptor (UR-II-R) was originally isolated as an orphan receptor (GPR14) from neural and sensory tissues.1,2 Urotensin II is expressed in various human tissues such as the CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5 Binding of urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that urotensin II is also expressed in various kinds of tumor cells such as adrenal tumors and neuroblastomas. In those cells, urotensin II was reported to stimulate cell growth.7-9

Alternative names: Urotensin II Receptor, Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14

Gene ID: 57305

NCBI Accession: NM_018949

UniProt: P49684