Recombinant CLEC4A antibody

Catalog No. ABIN7072449

Product Details anti-CLEC4A Antibody

Target: CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This CLEC4A antibody is un-conjugated

Application: Flow Cytometry (FACS)

Purpose: Anti-DCIR [9E8], Rabbit IgG, kappa

Specificity: This antibody is specific for human DCIR, which is expressed by monocytes, B cells, neutrophils, granulocytes and dendritic cells.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising BALB/c mice with a dendritic cell immunoreceptor ectodomain-human Fc fusion protein.

Clone: 9E8

Isotype: IgG kappa

Application Details

Application Notes: This antibody has been used in flow cytometric analysis of DCIR expression by peripheral blood mononuclear cells (Klechevsky et al, 2010). A recombinant humanised form of this antibody fused to protein antigens is under investigation as an antigen-targeting vaccine (Flamar et al, 2012), and has been shown to trigger antigen-specific CD8+ T cell immunity.

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CLEC4A

Target: CLEC4A (C-Type Lectin Domain Family 4, Member A (CLEC4A))

Alternative Name: DCIR (CLEC4A Products)

Background: CD367, Clec4A, C-type lectin domain family 4 member A, LLIR, CLECSF6, C-type lectin DDB27, C-type lectin superfamily member 6, Dendritic cell immunoreceptor, Lectin-like immunoreceptor