Chloride Channel 5 antibody

Catalog No. ABIN7073471

This Rabbit Polyclonal antibody specifically detects Chloride Channel 5 in IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Chloride Channel 5 antibody (ABIN7073471)

Target: Chloride Channel 5 (CLCN5)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Chloride Channel 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Chloride Channel 5 Antibody

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ClC-5

Application Details

Application Notes: IHC/IF (H,M,R) 1:100-1:400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Chloride Channel 5

Target: Chloride Channel 5 (CLCN5)

Alternative Name: ClC-5

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria.

Gene ID: 12728

NCBI Accession: NP_001230691

UniProt: Q9WVD4