Thymidine Phosphorylase antibody (AA 121-220)

Catalog No. ABIN704441

The Rabbit Polyclonal anti-Thymidine Phosphorylase antibody has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect Thymidine Phosphorylase in samples from Human.

Quick Overview for Thymidine Phosphorylase antibody (AA 121-220) (ABIN704441)

Target: Thymidine Phosphorylase (TYMP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Thymidine Phosphorylase antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Thymidine Phosphorylase Antibody

Binding Specificity: AA 121-220

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Thymidine Phosphorylase

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Thymidine Phosphorylase

Target: Thymidine Phosphorylase (TYMP)

Alternative Name: TP/thymidine phosphorylase

Background:

Synonyms: ECGF 1, PDEGF, ECGF1, Endothelial cell growth factor 1, Endothelial cell growth factor 1 platelet derived, Gliostatin, hPD ECGF, MNGIE, PD ECGF, PDECGF, PDEGF, Platelet derived endothelial growth factor, TdRPase, TP, TYMP, Thymidine Phosphorylase, TYPH_HUMAN, TdRPase.

Background: In the presence of inorganic orthophosphate, the platelet-derived endothelial growth factor (PD-ECGF) thymidine phosphorylase (TP) (gliostatin) catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.

Gene ID: 1890

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2