PGC1 alpha + beta antibody

Catalog No. ABIN7075028

This Rabbit Polyclonal antibody specifically detects in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PGC1 alpha + beta antibody (ABIN7075028)

Target: PGC1 alpha + beta

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Product Details

Cross-Reactivity: Mouse, Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Human PGC1alpha+beta

Application Details

Application Notes: WB (H,M,R) 1: 500-1: 1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: PGC1 alpha + beta

Background: PGC-1αis a transcriptional coactivator that regulates the genes involved in energy metabolism. It is the master regulator of mitochondrial biogenesis. This protein interacts with the nuclear receptor PPAR-γ, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element-binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor causing slow-twitch rather than fast-twitch muscle fiber types. Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. Exercise-induced PGC-1αin skeletal muscle increases autophagy and unfolded protein response. PGC-1α protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

Molecular Weight: 91 kDa

Gene ID: 19017

NCBI Accession: NP_001317680

UniProt: Q9UBK2