Sarcomeric alpha Actinin antibody

Catalog No. ABIN7075510

The Rabbit Polyclonal anti-Sarcomeric alpha Actinin antibody (ABIN7075510) specifically detects Sarcomeric alpha Actinin in WB, IEM, IF and IHC. The antibody is reactive with Mouse and Rat samples.

Quick Overview for Sarcomeric alpha Actinin antibody (ABIN7075510)

Target: Sarcomeric alpha Actinin

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB), Immunoelectron Microscopy (IEM), Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse alpha Actinin 2

Application Details

Application Notes: WB (M,R) 1:2000, IHC/IF ,IEM (M,R) 1:500-1:1000/1:2000/1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details

Target: Sarcomeric alpha Actinin

Background: The primary function of alpha-actinin 2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton etal. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin 2 also functions in docking signaling molecules at Z-discs, and additional studies have also implicated alpha-actinin 2 in the binding of cardiac ion channels, Kv1.5 in particular.

Molecular Weight: 104 kDa

Gene ID: 11472

NCBI Accession: NP_150371

UniProt: Q9JI91