TCF7 antibody

Catalog No. ABIN7075952

Product Details anti-TCF7 Antibody

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF7 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse TCF7

Application Details

Application Notes: IHC/IF (M,R) 1:600-1:1200/1:600-1:1200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TCF7

Target: TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box) (TCF7))

Alternative Name: TCF7 (TCF7 Products)

Background: TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Gene ID: 21414

NCBI Accession: NP_001300910

UniProt: Q00417

Pathways: WNT Signaling