CD276 antibody (Biotin)

Catalog No. ABIN7077083

This Mouse Monoclonal antibody specifically detects CD276 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD276 antibody (Biotin) (ABIN7077083)

Target: CD276

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD276 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: DCN-70

Product Details anti-CD276 Antibody (Biotin)

Purpose: CD276 Biotin Antibody

Characteristics: The clone DCN.70, a mouse monoclonal antibody selectively binds with a k type I membrane protein commonly known as CD276, a member of B7-H3 immunoregulatory family. It is not expressed by lymphocytes or granulocytes but weakly expressed on resting monocytes. Increased expression is observed on monocytes derived dendritic cells as well as in a variety of cancer types, including breast, pancreatic, and ovarian cancer. CD276 expression has been correlated with poor survival in ovarian cancer subjects. CD276 blockade, especially when combined with an anti-PD-1 blockade, is a promising strategy for the treatment of B7-H3-expressing NSCLCs that arerefractory to anti-PD-1 therapy, making CD276 a promising clinical molecular target.

Purification: Purified

Purity: >95 %

Immunogen: Human Dendritic Cells

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2-8°C, Conjugated antibodies should never be frozen.

Target Details for CD276

Target: CD276

Alternative Name: CD276

Gene ID: 80381

UniProt: Q5ZPR3

Pathways: Cancer Immune Checkpoints