XRN1 antibody (AA 200-450)

Catalog No. ABIN7111134

This anti-XRN1 antibody is a Rabbit Polyclonal antibody detecting XRN1 in WB, IHC, ELISA and IF. Suitable for Human and Mouse.

Quick Overview for XRN1 antibody (AA 200-450) (ABIN7111134)

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRN1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-XRN1 Antibody

Binding Specificity: AA 200-450

Purpose: XRN1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 200-450aa

Immunogen: 5'-3' exoribonuclease 1

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for XRN1

Target: XRN1 (5'-3' Exoribonuclease 1 (XRN1))

Alternative Name: XRN1

Background:

Synonyms: 5'-3' exoribonuclease 1|Strand-exchange protein 1 homolog|XRN1|45536

Background: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA(By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma(OGS).

Molecular Weight: 192 kDa

Gene ID: 54464

UniProt: Q8IZH2