ADCY6 antibody

Catalog No. ABIN7111340

The Rabbit Polyclonal anti-ADCY6 antibody has been validated for WB, ELISA and IP. It is suitable to detect ADCY6 in samples from Human, Mouse and Rat.

Quick Overview for ADCY6 antibody (ABIN7111340)

Target: ADCY6 (Adenylate Cyclase 6 (ADCY6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADCY6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-ADCY6 Antibody

Purpose: ADCY6 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: adenylate cyclase 6

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ADCY6

Target: ADCY6 (Adenylate Cyclase 6 (ADCY6))

Alternative Name: ADCY6

Background:

Synonyms: Adenylate cyclase type 6|ATP pyrophosphate-lyase 6|Adenylate cyclase type VI|Adenylyl cyclase 6|Ca(2+)-inhibitable adenylyl cyclase|ADCY6|KIAA0422

Background: Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors(PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells(PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion(By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function(By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol(PubMed:17916776). Contributes to bone cell responses to mechanical stimuli(By similarity).

Molecular Weight: 131 kDa

Gene ID: 112

UniProt: O43306

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma