BVES antibody

Catalog No. ABIN7112013

The Rabbit Polyclonal anti-BVES antibody (ABIN7112013) specifically detects BVES in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for BVES antibody (ABIN7112013)

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BVES antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-BVES Antibody

Purpose: BVES antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: blood vessel epicardial substance

Isotype: IgG

Application Details

Application Notes: WB: 1:100-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BVES

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Alternative Name: BVES

Background:

Synonyms: Blood vessel epicardial substance (hBVES)|Popeye domain-containing protein 1 (Popeye protein 1)|BVES|POP1|POPDC1

Background: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction(TJ) paracellular permeability barrier in epithelial cells(PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading(By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density(PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Molecular Weight: 41-70 kDa

Gene ID: 11149

UniProt: Q8NE79