BEX2 antibody

Catalog No. ABIN7112040

This anti-BEX2 antibody is a Rabbit Polyclonal antibody detecting BEX2 in ELISA, IHC and WB. Suitable for Human, Mouse and Rat.

Quick Overview for BEX2 antibody (ABIN7112040)

Target: BEX2 (Brain Expressed X-Linked 2 (BEX2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BEX2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-BEX2 Antibody

Purpose: BEX2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: brain expressed X-linked 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for BEX2

Target: BEX2 (Brain Expressed X-Linked 2 (BEX2))

Alternative Name: BEX2

Background:

Synonyms: Protein BEX2|Brain-expressed X-linked protein 2 (hBex2)|BEX2

Background: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. The homology between human BEX1 and BEX2 is 94 % . This antibody detects both BEX1 and BEX2.

Molecular Weight: 10-15 kDa

Gene ID: 84707

UniProt: Q9BXY8