CEP152 antibody

Catalog No. ABIN7112602

This Rabbit Polyclonal antibody specifically detects CEP152 in ELISA, WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for CEP152 antibody (ABIN7112602)

Target: CEP152 (Centrosomal Protein 152kDa (CEP152))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP152 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-CEP152 Antibody

Purpose: CEP152 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: centrosomal protein 152kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CEP152

Target: CEP152 (Centrosomal Protein 152kDa (CEP152))

Alternative Name: CEP152

Background:

Synonyms: Centrosomal protein of 152 kDa (Cep152)|CEP152|KIAA0912

Background: Necessary for centrosome duplication, the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication(PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 Molecules involved in centriole formation(PubMed:21059844, PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure(PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles(By similarity). Overexpression of CEP152 can drive amplification of centrioles(PubMed:20852615).

Molecular Weight: 110 kDa

Gene ID: 22995

UniProt: O94986

Pathways: M Phase