Claspin antibody

Catalog No. ABIN7112861

The Rabbit Polyclonal anti-Claspin antibody has been validated for WB, ELISA, IP and IF. It is suitable to detect Claspin in samples from Human.

Quick Overview for Claspin antibody (ABIN7112861)

Target: Claspin (CLSPN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claspin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-Claspin Antibody

Purpose: CLSPN antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: claspin homolog(Xenopus laevis)

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IP: 1:500-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Claspin

Target: Claspin (CLSPN)

Alternative Name: CLSPN

Background:

Synonyms: Claspin (hClaspin)|CLSPN

Background: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex(pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks.

Molecular Weight: 240 kDa

Gene ID: 63967

UniProt: Q9HAW4